Activation and regulation of purinergic P2X receptor channels
Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
P2X receptors in health and disease
G Burnstock, C Kennedy - Advances in pharmacology, 2011 - Elsevier
Seven P2X receptor subunits have been cloned which form functional homo-and
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …
Adenosine and ATP receptors in the brain
G Burnstock, BB Fredholm… - Current topics in …, 2011 - ingentaconnect.com
There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the
brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic …
brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic …
Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: a calcium imaging study
R Kushnir, PS Cherkas, M Hanani - Neuropharmacology, 2011 - Elsevier
Satellite glial cells (SGCs) in sensory ganglia are altered structurally and biochemically as a
result of nerve injury. Whereas there is ample evidence that P2 purinergic receptors in …
result of nerve injury. Whereas there is ample evidence that P2 purinergic receptors in …
Facilitation of glutamate and GABA release by P2X receptor activation in supraoptic neurons from freshly isolated rat brain slices
V Vavra, A Bhattacharya, H Zemkova - Neuroscience, 2011 - Elsevier
The supraoptic nuclei (SON), the hypothalamic release site of vasopressin and oxytocin,
receive a non-glutamatergic, excitatory input from the caudal medulla that uses …
receive a non-glutamatergic, excitatory input from the caudal medulla that uses …
The carbon monoxide donor, CORM-2, is an antagonist of ATP-gated, human P2X4 receptors
WJ Wilkinson, PJ Kemp - Purinergic signalling, 2011 - Springer
Carbon monoxide (CO) is produced endogenously by heme oxygenase (HO) enzymes. HO-
1 is highly expressed in many inflammatory disease states, where it is broadly protective …
1 is highly expressed in many inflammatory disease states, where it is broadly protective …
Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated
E Richler, E Shigetomi, BS Khakh - Journal of Neuroscience, 2011 - Soc Neuroscience
ATP-gated ionotropic P2X2 receptors are widely expressed in neurons. Although the
electrophysiological properties of P2X2 receptors have been extensively studied, little is …
electrophysiological properties of P2X2 receptors have been extensively studied, little is …
[HTML][HTML] The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels
RC Allsopp, RJ Evans - Journal of Biological Chemistry, 2011 - ASBMB
P2X receptors show marked variations in the time-course of response to ATP application
from rapidly desensitizing P2X1 receptors to relatively sustained P2X2 receptors. In this …
from rapidly desensitizing P2X1 receptors to relatively sustained P2X2 receptors. In this …
[HTML][HTML] Regulation of GABAA receptor dynamics by interaction with purinergic P2X2 receptors
γ-Aminobutyric acid type A receptors (GABA A Rs) in the spinal cord are evolving as an
important target for drug development against pain. Purinergic P2X 2 receptors (P2X 2 Rs) …
important target for drug development against pain. Purinergic P2X 2 receptors (P2X 2 Rs) …
Regional expression of P2Y4 receptors in the rat central nervous system
Abstract P2Y receptors are G protein-coupled receptors composed of eight known subunits
(P2Y 1, 2, 4, 6, 11, 12, 13, 14), which are involved in different functions in neural tissue. The …
(P2Y 1, 2, 4, 6, 11, 12, 13, 14), which are involved in different functions in neural tissue. The …