Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular processes
Great progress has been made in understanding the regulation of expression of genes
involved in secondary metabolism. Less is known about the mechanisms that govern the …
involved in secondary metabolism. Less is known about the mechanisms that govern the …
[HTML][HTML] Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis
CA Desjardins, MD Champion, JW Holder… - PLoS …, 2011 - journals.plos.org
Paracoccidioides is a fungal pathogen and the cause of paracoccidioidomycosis, a health-
threatening human systemic mycosis endemic to Latin America. Infection by …
threatening human systemic mycosis endemic to Latin America. Infection by …
The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial
B Dalmais, J Schumacher, J Moraga… - Molecular plant …, 2011 - Wiley Online Library
The grey mould fungus Botrytis cinerea produces two major phytotoxins, the sesquiterpene
botrydial, for which the biosynthesis gene cluster has been characterized previously, and the …
botrydial, for which the biosynthesis gene cluster has been characterized previously, and the …
Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum
TB Regueira, KR Kildegaard, BG Hansen… - Applied and …, 2011 - Am Soc Microbiol
Mycophenolic acid (MPA) is the active ingredient in the increasingly important
immunosuppressive pharmaceuticals CellCept (Roche) and Myfortic (Novartis). Despite the …
immunosuppressive pharmaceuticals CellCept (Roche) and Myfortic (Novartis). Despite the …
A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans
ML Nielsen, JB Nielsen, C Rank… - FEMS microbiology …, 2011 - academic.oup.com
Fungi possess an advanced secondary metabolism that is regulated and coordinated in a
complex manner depending on environmental challenges. To understand this complexity, a …
complex manner depending on environmental challenges. To understand this complexity, a …
Insights from the first putative biosynthetic gene cluster for a lichen depside and depsidone
D Armaleo, X Sun, C Culberson - Mycologia, 2011 - Taylor & Francis
The genes for polyketide synthases (PKSs), enzymes that assemble the carbon backbones
of many secondary metabolites, often cluster with other secondary pathway genes. We …
of many secondary metabolites, often cluster with other secondary pathway genes. We …
Allergens/Antigens, Toxins and Polyketides of Important Aspergillus Species
The medical, agricultural and biotechnological importance of the primitive eukaryotic
microorganisms, the Fungi was recognized way back in 1920. Among various groups of …
microorganisms, the Fungi was recognized way back in 1920. Among various groups of …
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization …
The linear tetracyclic TAN-1612 (1) and BMS-192548 (2) were isolated from different
filamentous fungal strains and have been examined as potential neuropeptide Y and …
filamentous fungal strains and have been examined as potential neuropeptide Y and …
[HTML][HTML] Interkingdom gene transfer of a hybrid NPS/PKS from bacteria to filamentous ascomycota
Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary
metabolites produced by bacteria and fungi using multidomain enzymes called …
metabolites produced by bacteria and fungi using multidomain enzymes called …
Identification of a biosynthesis gene cluster for flocculosin a cellobiose lipid produced by the biocontrol agent Pseudozyma flocculosa
B Teichmann, C Labbé, F Lefebvre… - Molecular …, 2011 - Wiley Online Library
Flocculosin is an antifungal glycolipid produced by the biocontrol fungus Pseudozyma
flocculosa. It consists of cellobiose, O‐glycosidically linked to 3, 15, 16‐trihydroxypalmitic …
flocculosa. It consists of cellobiose, O‐glycosidically linked to 3, 15, 16‐trihydroxypalmitic …