Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a
broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity …

Recombinant baculoviruses (rBac) are used for many different applications, ranging from bio-
insecticides to the production of heterologous proteins, high-throughput screening of gene …

Background Stoichiometric models constitute the basic framework for fluxome quantification
in the realm of metabolic engineering. A recurrent bottleneck, however, is the establishment …

Although viruses are simple biological systems, they are capable of evolving highly efficient
techniques for infecting cells, expressing their genomes, and generating new copies of …

Although glucose is the primary cerebral fuel, the brain is able to metabolize other
substrates in hypoglycemia. Nevertheless, the metabolic consequences of this pathology at …

Baculovirus infection of Spodoptera frugiperda cells is a system of choice to produce a
range of recombinant proteins, vaccines and, potentially, gene therapy vectors. While …

Background While functional genomics, focused on gene functions and gene-gene
interactions, has become a very active field of research in molecular biology, equivalent …

Lactate and ammonia are the most important waste products of central carbon metabolism in
mammalian cell cultures. In particular during batch and fed‐batch cultivations these toxic by …

Baculoviruses have proven capacity for the production of recombinant proteins including
virus-like particles and as viral vectors. Recent progress in preclinical studies suggest that …