Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …

Tissue fibrosis is a major cause of morbidity, and idiopathic pulmonary fibrosis (IPF) is a
terminal illness characterized by unremitting matrix deposition in the lung. The mechanisms …

The pleiotropic growth factor TGFβ1 promotes many of the pathogenic mechanisms
observed in lung fibrosis and airway remodeling, such as aberrant extracellular matrix …

During wound healing, contractile fibroblasts called myofibroblasts regulate the formation
and contraction of granulation tissue; however, pathological and persistent myofibroblast …

The molecular mechanisms of lung injury and fibrosis are incompletely understood.
MicroRNAs (miRNAs) are crucial biological regulators that act by suppressing their target …

Idiopathic pulmonary fibrosis is a progressive disease that causes unremitting extracellular
matrix deposition with resulting distortion of pulmonary architecture and impaired gas …

The chemokine, CXCL10, and its cognate receptor, CXCR3, are important mediators of the
pathobiology of lung fibrosis. Macrophages are a known source of CXCL10, but their …