Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation
and to allow for tissue repair and the return to homeostasis after infection and tissue injury …

The pathogenic origin of autoimmune diseases can be traced to both genetic susceptibility
and epigenetic modifications arising from exposure to the environment. Epigenetic …

The potential roles of epigenetic alterations in the pathogenesis of autoimmune rheumatic
diseases are raising great expectations among clinicians and researchers. Epigenetic …

Porphyromonas gingivalis is a pathogen in severe periodontal disease. Able to exploit an
intracellular lifestyle within primary gingival epithelial cells (GECs), a reservoir of P …

Understanding the molecular basis of wound healing and regeneration in vertebrates is one
of the main challenges in biology and medicine. This understanding will lead to medical …

MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded RNAs about 21
nucleotides in length. miRNAs have been shown to regulate gene expression and thus …

Rheumatoid arthritis (RA) is a chronic and severe autoimmune disease that affects joint
tissues, bone, and cartilage. However, the pathogenesis of RA is still unclear …

The transcription factor NF-κB plays crucial roles in the regulation of inflammation and
mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune …

Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Synovial fibroblasts are recognized as key cells in the pathogenesis of RA since they attract …

The key regular functions of microRNAs (miRNAs) were only discovered a few years ago,
when it became evident that miRNAs play important roles in gene regulation. Today, more …