Blood contains microparticles (MPs) derived from a variety of cell types, including platelets,
monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs …

When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

Membrane-shed submicron microparticles (MPs) are released after cell activation or
apoptosis. High levels of MPs circulate in the blood of patients with atherothrombotic …

Evolving studies in models of transplant rejection, inflammatory bowel disease, and cancer,
among others, have implicated purinergic signaling in clinical manifestations of vascular …

Venous thromboembolism (VTE) is a leading cause of morbidity and mortality worldwide.
However, the mechanisms by which clots are formed in the deep veins have not been …

Blood microparticles are vesicular structures with a diameter of 100 to 1000 nm that are
present in the blood of normal subjects and in patients with various diseases. These …

Thrombosis is initiated by tissue factor (TF), a coagulation cofactor/receptor expressed in the
vessel wall, on myeloid cells, and on microparticles (MPs) with variable procoagulant …

Plasma membrane remodeling characterized by phosphatidylserine exposure and
consecutive microparticle (MP) shedding is an ubiquitous process enabling the clearance of …

Atherosclerosis and its thrombotic complications are responsible for remarkably high
numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental …

Extracellular nucleotides are ubiquitous signalling molecules, acting via the P2 class of
surface receptors. Platelets express three P2 receptor subtypes, ADP-dependent P2Y1 and …