Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …

Post translational modification of histones and non-histone proteins by acetylation play a key
role in tumourigenesis. Histone deacetylases (HDACs) are enzymes involved in remodelling …

Post-translational modifications of the histones are centrally involved in the regulation of all
DNA-templated processes, including gene transcription, DNA replication, recombination …

Histone deacetylase (HDAC) inhibitors are currently used clinically as anticancer drugs.
Recent data have demonstrated that some of these drugs have potent antiinflammatory or …

During mammalian embryonic development, DNA methylation and histone modifications are
important in gene expression regulation and epigenetic reprogramming. In cloned embryos …

The etiology of a variety of chronic inflammatory disorders has been attributed to the
interaction of genetic and environmental factors. Herein, we identified a link between …

Silent information regulator 2 (Sir2) enzymes or sirtuins are a family of intracellular protein
deacetylases that can catalyze the β-nicotinamide adenine dinucleotide (β-NAD+) …

Bisubstrate‐type compound Lys‐CoA has been shown to inhibit the p300 histone acetyl
transferase activity efficiently and may constitute a lead compound for a novel class of …

Myelodysplastic syndrome (MDS) represents a heterogeneous group of diseases with clonal
proliferation, bone marrow failure and increasing risk of transformation into an acute myeloid …

Pituitary adenomas are benign endocrine tumours of the anterior pituitary that are
subclassified as typical (conventional) or atypical adenomas, with uncertain prognosis …