The MHC, disease and selection
J Trowsdale - Immunology letters, 2011 - Elsevier
Given large sample sizes, whole genome screens are now able to identify even quite
modest contributions of common human genetic variation to disease. These approaches …
modest contributions of common human genetic variation to disease. These approaches …
[HTML][HTML] Autoimmune hepatitis, HLA and extended haplotypes
LC Oliveira, G Porta, MLC Marin, PL Bittencourt… - Autoimmunity …, 2011 - Elsevier
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease. Characteristic liver-
infiltrating immune cells in portal and periportal areas, hypergammaglobulinemia and typical …
infiltrating immune cells in portal and periportal areas, hypergammaglobulinemia and typical …
HLA-A* 3101 and carbamazepine-induced hypersensitivity reactions in Europeans
M McCormack, A Alfirevic, S Bourgeois… - … England Journal of …, 2011 - Mass Medical Soc
Background Carbamazepine causes various forms of hypersensitivity reactions, ranging
from maculopapular exanthema to severe blistering reactions. The HLA-B* 1502 allele has …
from maculopapular exanthema to severe blistering reactions. The HLA-B* 1502 allele has …
Genome-wide association study identifies susceptibility loci for IgA nephropathy
We carried out a genome-wide association study of IgA nephropathy, a major cause of
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …
Pervasive sharing of genetic effects in autoimmune disease
Genome-wide association (GWA) studies have identified numerous, replicable, genetic
associations between common single nucleotide polymorphisms (SNPs) and risk of …
associations between common single nucleotide polymorphisms (SNPs) and risk of …
The shaping of modern human immune systems by multiregional admixture with archaic humans
L Abi-Rached, MJ Jobin, S Kulkarni, A McWhinnie… - Science, 2011 - science.org
Whole genome comparisons identified introgression from archaic to modern humans. Our
analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system …
analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system …
Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles
BACKGROUND & AIMS: Drug-induced liver injury (DILI), especially from antimicrobial
agents, is an important cause of serious liver disease. Amoxicillin-clavulanate (AC) is a …
agents, is an important cause of serious liver disease. Amoxicillin-clavulanate (AC) is a …
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma
To identify the genetic susceptibility factor (s) for hepatitis C virus–induced hepatocellular
carcinoma (HCV-induced HCC), we conducted a genome-wide association study using …
carcinoma (HCV-induced HCC), we conducted a genome-wide association study using …
Whole-genome molecular haplotyping of single cells
Conventional experimental methods of studying the human genome are limited by the
inability to independently study the combination of alleles, or haplotype, on each of the …
inability to independently study the combination of alleles, or haplotype, on each of the …
Next-generation sequencing for HLA typing of class I loci
RL Erlich, X Jia, S Anderson, E Banks, X Gao… - BMC genomics, 2011 - Springer
Background Comprehensive sequence characterization across the MHC is important for
successful organ transplantation and genetic association studies. To this end, we have …
successful organ transplantation and genetic association studies. To this end, we have …