Transactive response DNA-binding protein of 43 kDa (TDP-43), an RNA and DNA binding
protein involved in transcriptional repression, RNA splicing and RNA metabolism during the …

Mutation of human GRN, the gene encoding the secreted glycoprotein progranulin, results in
a form of frontotemporal lobar degeneration that is characterized by the presence of …

We used cross-linking and immunoprecipitation coupled with high-throughput sequencing to
identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding …

Progranulin (GRN) mutations cause frontotemporal dementia (FTD), but GRN's function in
the CNS remains largely unknown. To identify the pathways downstream of GRN, we used …

Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the
second most common cause of early-onset dementia. Mutations in the progranulin gene are …

Progranulin (PGRN) is an autocrine growth factor with multiple functions. This review
provides updates about the interplays of PGRN with extracellular matrix proteins, proteolytic …

Progranulin is a fascinating multifunctional protein, which has been implicated in cell growth,
wound repair, tumorigenesis, inflammation, neurodevelopment, and more recently in …

Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD)
with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin …

We collected a massive and heterogeneous dataset of 20 255 gene expression profiles
(GEPs) from a variety of human samples and experimental conditions, as well as 8895 GEPs …

To reduce damage from toxic insults such as glutamate excitotoxicity and oxidative stresses,
neurons may deploy an array of neuroprotective mechanisms. Recent reports show that …