[HTML][HTML] Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and …
OBJECTIVE: To clarify the role of common genetic variation in the Interleukin-1β (IL1B) and
Interleukin-1R antagonist (IL1RN) genes on risk of knee and hip osteoarthritis (OA) and …
Interleukin-1R antagonist (IL1RN) genes on risk of knee and hip osteoarthritis (OA) and …
Human metabolic individuality in biomedical and pharmaceutical research
Genome-wide association studies (GWAS) have identified many risk loci for complex
diseases, but effect sizes are typically small and information on the underlying biological …
diseases, but effect sizes are typically small and information on the underlying biological …
Meta-analysis of genome-wide association studies in> 80 000 subjects identifies multiple loci for C-reactive protein levels
Background—C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …
strongly associated with cardiovascular disease. We sought to identify genetic variants that …
New gene functions in megakaryopoiesis and platelet formation
C Gieger, A Radhakrishnan, A Cvejic, W Tang, E Porcu… - Nature, 2011 - nature.com
Platelets are the second most abundant cell type in blood and are essential for maintaining
haemostasis. Their count and volume are tightly controlled within narrow physiological …
haemostasis. Their count and volume are tightly controlled within narrow physiological …
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
Diabetes impacts approximately 200 million people worldwide, of whom approximately 10%
are affected by type 1 diabetes (T1D). The application of genome-wide association studies …
are affected by type 1 diabetes (T1D). The application of genome-wide association studies …
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …
chronic obstructive pulmonary disease. We tested genome-wide association with forced …
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk
Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone
mineral density (BMD) is a major predisposing factor to fracture and is known to be highly …
mineral density (BMD) is a major predisposing factor to fracture and is known to be highly …
The genetics of bone loss: challenges and prospects
BD Mitchell, LM Yerges-Armstrong - The Journal of Clinical …, 2011 - academic.oup.com
Context: A strong genetic influence on bone mineral density has been long established, and
modern genotyping technologies have generated a flurry of new discoveries about the …
modern genotyping technologies have generated a flurry of new discoveries about the …
Common genetic variants associated with open-angle glaucoma
WD Ramdas, LME van Koolwijk… - Human molecular …, 2011 - academic.oup.com
Open-angle glaucoma (glaucoma) is a major eye disorder characterized by optic disc
pathology. Recent genome-wide association studies identified new loci associated with …
pathology. Recent genome-wide association studies identified new loci associated with …
[图书][B] Introduction to clinical nutrition
V Sardesai - 2011 - books.google.com
Dietary factors have been implicated in at least four of the ten leading causes of death in the
US (heart disease, cancer, diabetes, and stroke). Nevertheless, physicians frequently …
US (heart disease, cancer, diabetes, and stroke). Nevertheless, physicians frequently …