VEGFs (vascular endothelial growth factors) control vascular development during
embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There …

During angiogenesis, αv integrins are overexpressed on the endothelial cell surface to
facilitate the growth and survival of newly forming vessels. Accordingly, blocking αv integrin …

Integrin-mediated cell adhesion is involved in many essential normal cellular and
pathological functions including cell survival, growth, differentiation, migration, inflammatory …

Integrins on both tumor cells and the supporting host stromal cells in bone (osteoclasts, new
blood vessels, inflammatory cells, platelets and bone marrow stromal cells) play key roles in …

Integrins are a family of cell-extracellular matrix adhesion molecules that play important
roles in tumor angiogenesis. αvβ3-Integrin has received much attention as a potential anti …

Endorepellin, the C-terminal module of perlecan, negatively regulates angiogenesis counter
to its proangiogenic parental molecule. Endorepellin (the C-terminal domain V of perlecan) …

Vascular endothelial growth factor (VEGF) acting through VEGF receptor 2 (VEGFR2) on
endothelial cells (ECs) is a key regulator of angiogenesis, a process essential for wound …

Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis.
Transformed epithelial cells can switch to a motile, mesenchymal phenotype by epithelial …

The term angiogenesis arose in the 18th century. Several studies over the next 100 years
laid the groundwork for initial studies performed by the Folkman laboratory, which were at …

Kindlin-2, a widely distributed cytoskeletal protein, has been implicated in integrin activation,
and its absence is embryonically lethal in mice and causes severe developmental defects in …