Vestibular hair cells and afferents: two channels for head motion signals

RA Eatock, JE Songer - Annual review of neuroscience, 2011 - annualreviews.org
Vestibular epithelia of the inner ear detect head motions over a wide range of amplitudes
and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of …

Principles of unconventional myosin function and targeting

MA Hartman, D Finan… - Annual review of cell …, 2011 - annualreviews.org
Unconventional myosins are a superfamily of actin-based motors implicated in diverse
cellular processes. In recent years, much progress has been made in describing their …

Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

M Grati, B Kachar - Proceedings of the National Academy of …, 2011 - National Acad Sciences
In the most accepted model for hair cell mechanotransduction, a cluster of myosin motors
located at the stereocilia upper tip-link density (UTLD) keeps the tip-link under tension at …

Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction

AW Peng, FT Salles, B Pan, AJ Ricci - Nature communications, 2011 - nature.com
Mechanosensation is a primitive and somewhat ubiquitous sense. At the inner ear, sensory
hair cells are refined to enhance sensitivity, dynamic range and frequency selectivity. Thirty …

Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification?

AW Peng, AJ Ricci - Hearing research, 2011 - Elsevier
Hearing organs have evolved to detect sounds across several orders of magnitude of both
intensity and frequency. Detection limits are at the atomic level despite the energy …

A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity

T Lin, MJ Greenberg, JR Moore, EM Ostap - Biochemistry, 2011 - ACS Publications
myo1c is a member of the myosin superfamily that has been proposed to function as the
adaptation motor in vestibular and auditory hair cells. A recent study identified a myo1c point …

The physical basis of active mechanosensitivity by the hair-cell bundle

J Barral, P Martin - Current Opinion in Otolaryngology & Head and …, 2011 - journals.lww.com
The physical basis of active mechanosensitivity by the hair-... : Current Opinion in
Otolaryngology & Head and Neck Surgery The physical basis of active mechanosensitivity by …

Functions of myosin motor proteins in the nervous system

DM Suter - Neurobiology of Actin: From Neurulation to Synaptic …, 2011 - Springer
The myosin superfamily consists of 24 classes of actin-based molecular motors that carry out
a diverse array of cellular functions ranging from cell motility and morphology to cytokinesis …