Tubulin protein is one of several members of a small family of globular proteins. It offers a
potential target for anticancer drug design and development. Combretastatin A-4 (CA-4) is a …

Microtubule-Targeting Agents (MTAs) constitute a class of drugs largely used for cancer
treatment in adults and children. In cancer cells, they suppress microtubule dynamics, and …

A series of azetidin-2-ones substituted at positions 1, 3 and 4 of the azetidinone ring scaffold
were synthesised and evaluated for antiproliferative, cytotoxic and tubulin-binding activity. In …

Sixty-one phenyl 4-(2-oxoimidazolidin-1-yl) benzenesulfonates (PIB-SOs) and 13 of their
tetrahydro-2-oxopyrimidin-1 (2 H)-yl analogues (PPB-SOs) were prepared and biologically …

Glucokinase is a key regulator of glucose homeostasis and small molecule activators of this
enzyme represent a promising opportunity for the treatment of Type 2 diabetes. Several …

The structure-activity relationships of antiproliferative β-lactams, focusing on modifications at
the 4-position of the β-lactam ring, is described. Synthesis of this series of compounds was …

The importance of the bridge linking the two phenyl moieties of substituted phenyl 4-(2-
oxoimidazolidin-1-yl) benzenesulfonates (PIB-SOs) was assessed using a sulfonamide …

A structural investigation on the isoxazole scaffold led to the discovery of 3, 4-
isoxazolediamide compounds endowed with potent Hsp90 inhibitory properties. We have …

Combretastatin A-4 (CA-4), its analogues and their excellent antitumoral and antivascular
activities, have attracted considerable interest of medicinal chemists. In this article, a docking …

In a cell-based screen of novel antiproliferative agents, the hit compound 1a, which bears a
benzofuransulfonamide scaffold, exhibited broad-spectrum antiproliferative activities against …