Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …

Atrial fibrillation (AF) is of public health importance and profoundly increases morbidity,
mortality, and healthrelated expenditures. Morbidities include the increased risks of …

Background—Intergenic variations on chromosome 4q25, close to the PITX2 transcription
factor gene, are associated with atrial fibrillation (AF). We therefore tested whether adult …

Rationale: Inhibitors of histone deacetylases (HDACs) reduce pressure-overload–induced
left ventricular hypertrophy and dysfunction, but their effects on right ventricular (RV) …

Interest for the pulmonary veins has increased in the past decade after the potential
arrhythmogenicity of the myocardial sleeve surrounding these structures has been …

Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three
distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the …

BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and
a major source of the substantially increased morbidity and mortality. Growing studies …

Despite some common risk factors for atrial fibrillation (AF) being more prevalent among
blacks, African Americans are increasingly being reported with lower prevalence and …

Atrial fibrillation (AF) is the most frequent cardiac arrhythmia and is a major cause of
morbidity and mortality. Previous studies have established genetic defects as a risk factor for …

Background Genome-wide studies have shown that polymorphisms on chromosome 4q25,
16q22 and 1q21 correlate with atrial fibrillation (AF). However, the distribution of these …