Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and
secreted by white adipose tissue. Since its discovery, leptin has been found to have …

Abstract Food-grade Lactic Acid Bacteria (LAB) have been safely consumed for centuries by
humans in fermented foods. Thus, they are good candidates to develop novel oral vectors …

Obesity and its associated comorbidities represent one of the biggest public health
challenges facing the world today. The heritability of body weight is high, and genetic …

BACKGROUND The increase in the incidence of obesity has a substantial societal health
impact. Contrasting reports have been published on whether overweight and obesity affect …

[Frontiers in Bioscience 16, 1634-1650, January 1, 2011] 1634 Associations between
adipokines and obesity-related cancer Gilbert Page 1 [Frontiers in Bioscience 16, 1634-1650 …

Leptin is a pleiotropic cytokine‐like hormone that is involved in the regulation of energy
intake and expenditure, neuroendocrine function, immunity and lipid and glucose …

OBJECTIVE Leptin therapy improves insulin sensitivity in people with leptin deficiency, but it
is not known whether it improves insulin action in people who are not leptin deficient. The …

Background: Congenital leptin deficiency is a rare human genetic condition clinically
characterized by hyperphagia and acute weight gain usually during the first postnatal year …

If you have been to your local shopping mall recently and are older than 20 years of age,
you have witnessed the growing girth of many Americans. The United States is now the …