The genetics of asthma and allergic disease: a 21st century perspective
Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …
and environmental contributions. Recent genome‐wide association studies (GWAS) and …
Under pressure: the search for the essential mechanisms of hypertension
TM Coffman - Nature medicine, 2011 - nature.com
High blood pressure, or hypertension, is a very common disorder with a substantial impact
on public health because of its associated complications. Despite the high prevalence of …
on public health because of its associated complications. Despite the high prevalence of …
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
H Schunkert, IR König, S Kathiresan, MP Reilly… - Nature …, 2011 - nature.com
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
Patients with asthma, a major public health problem, are at high risk for serious disease from
influenza virus infection, but the pathogenic mechanisms by which influenza A causes …
influenza virus infection, but the pathogenic mechanisms by which influenza A causes …
The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses
H Kouzaki, K Iijima, T Kobayashi… - The Journal of …, 2011 - journals.aai.org
The molecular mechanisms underlying the initiation of innate and adaptive proallergic Th2-
type responses in the airways are not well understood. IL-33 is a new member of the IL-1 …
type responses in the airways are not well understood. IL-33 is a new member of the IL-1 …
Identification of IL6R and chromosome 11q13. 5 as risk loci for asthma
Background We aimed to identify novel genetic variants affecting asthma risk, since these
might provide novel insights into molecular mechanisms underlying the disease. Methods …
might provide novel insights into molecular mechanisms underlying the disease. Methods …
Arterial thrombus formation in cardiovascular disease
The pathogenesis of arterial thrombosis is complex and dynamic. Unlike venous thrombi,
arterial thrombi typically form under conditions of high blood flow and are mainly composed …
arterial thrombi typically form under conditions of high blood flow and are mainly composed …
[HTML][HTML] Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus
DS Cunninghame Graham, DL Morris… - PLoS …, 2011 - journals.plos.org
Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a
range of auto-antibodies and a diverse set of clinical phenotypes. Currently,∼ 8% of the …
range of auto-antibodies and a diverse set of clinical phenotypes. Currently,∼ 8% of the …
[HTML][HTML] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To
identify common genetic polymorphisms associated with CHD and its risk factors (LDL-and …
identify common genetic polymorphisms associated with CHD and its risk factors (LDL-and …
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population
Coronary artery disease (CAD) causes more than 700,000 deaths each year in China.
Previous genome-wide association studies (GWAS) in populations of European ancestry …
Previous genome-wide association studies (GWAS) in populations of European ancestry …