As early as the 19th century, OIH was observed in patients receiving morphine for pain. It
was recognized that a potent analgesic such as morphine could actually result in an …

Almost 50 years of clinical investigation has resulted in a large amount of literature
regarding pain and antidepressants, one of the first categories of drugs found effective for …

Transneuronal transport of neurotropic viruses is widely used to define the organization of
neural circuitry in the mature and developing nervous system. However, interconnectivity …

Genetic studies have become indispensable in understanding pain mechanisms, shedding
light on the role of monoamine pathways in pain modulation. The present study was aimed …

Background: Trigeminal neuralgia typically involves nerves supplying teeth, jaws and face of
older females. Though the etiology is usually obscure, different treatment modalities have …

INTRODUÇÃO: A osteoartrose de joelho (OAJ) é uma das patologias que mais afetam o
aparelho locomotor e interferem de forma considerável nas atividades da vida diária …

This work analyzes the role of cholecystokinin (CCK) receptors, dynorphin A1–17 and
descending facilitation originated in the rostral ventromedial medulla (RVM) on secondary …

Objectives It has been proposed that serotonin dysfunctions underlie the pathophysiology of
various mood disorders (including major depressive disorder, MDD) and chronic pain …

Painful vincristine (VCR) neuropathy is a frequent and dose-limiting problem in cancer
treatment. Here, we investigated how pain behavior is modulated in mice lacking the …

To investigate the pain-modulatory effects of a local inflammatory stimulus on pain
elsewhere in the body, capsaicin was applied topically to the forearm of 14 healthy female …