Galectin-3–a jack-of-all-trades in cancer

AU Newlaczyl, LG Yu - Cancer letters, 2011 - Elsevier
Galectin-3 is a mammalian β-galactoside-binding protein that is expressed by various types
of human cells. Changes in galectin-3 expression and subcellular and intercellular …

When galectins recognize glycans: from biochemistry to physiology and back again

S Di Lella, V Sundblad, JP Cerliani, CM Guardia… - Biochemistry, 2011 - ACS Publications
In the past decade, increasing efforts have been devoted to the study of galectins, a family of
evolutionarily conserved glycan-binding proteins with multifunctional properties. Galectins …

Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis

DM Okamura, K Pasichnyk… - American Journal …, 2011 - journals.physiology.org
Renal tubular cell apoptosis is a critical detrimental event that leads to chronic kidney injury
in association with renal fibrosis. The present study was designed to investigate the role of …

Galectin-3 (Gal-3) induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia

M Yamamoto-Sugitani, J Kuroda… - Proceedings of the …, 2011 - National Acad Sciences
Bone marrow (BM) microenvironment (BMME) constitutes the sanctuary for leukemic cells. In
this study, we investigated the molecular mechanisms for BMME-mediated drug resistance …

Regulated expression of galectin-3, a multifunctional glycan-binding protein, in haematopoietic and non-haematopoietic tissues

V Sundblad, DO Croci Russo, GA Rabinovich - 2011 - ri.conicet.gov.ar
Galectin-3 belongs to a family of highly conserved animal lectins characterized by their
ability to recognize multiple N-acetyllactosamine sequences, which can be displayed on …

Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells

T Kobayashi, T Shimura, T Yajima, N Kubo… - Clinical & experimental …, 2011 - Springer
Pancreatic cancer demonstrates a strong resistance to anticancer drugs, presumably due to
its resistance to drug induced apoptosis. Although gemcitabine (GEM) might be partially …

Selectively depolymerized galactomannan polysaccharide

D Platt, A Klyosov - US Patent 7,893,252, 2011 - Google Patents
5,498,702 A 3, 1996 Mitchell et al. diseases such as cancer. The compositions comprise one
or 5,502,199 A 3/1996 Angerbauer et al. more polysaccharides in an admixture with one or …

[PDF][PDF] 奥沙利铂联合低分子柑橘果胶对HCT116 细胞增殖的抑制作用及机制

汪峰, 刘海鹰 - 中国普通外科杂志, 2011 - zpwz.net
目的探讨奥沙利铂(LOHP) 联合低分子柑橘果胶(LcP) 对结肠癌HcT116 细胞增殖的抑制作用及
其机制. 方法MTT 法检测LOHP 单药及LOHP 联合LcP 对HcT116 细胞增殖的影响; …

Myenteric denervation downregulates galectin-1 and-3 expression in gastric carcinogenesis

CF Estofolete, S Zucoloto, SM Oliani… - Digestive diseases and …, 2011 - Springer
Background This study evaluated the galectin-1 and-3 expression during N-methyl-N′-nitro-
N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in denervated rat stomachs …

Role of galectin-3 in liver progenitor cell proliferation and differentiation

WC Hsieh - 2011 - era.ed.ac.uk
Liver progenitor cells (LPCs) respond to hepatic injury when hepatocyte division is impaired
in chronic or severe injury. The LPCs are intimately surrounded by myofibroblasts …