Preservation of female genetics is currently done primarily by means of oocyte and embryo
cryopreservation. The field has seen much progress during its four-decade history, progress …

Idiopathic hypogonadotropic hypogonadism (IHH) is defined by absent or incomplete
puberty and characterised biochemically by low levels of sex steroids, with low or …

Abstract Context: Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-
10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been …

Adrenarche reflects the maturation of the adrenal zona reticularis resulting in increased
secretion of the adrenal androgen precursor DHEA and its sulphate ester DHEAS …

Sexual Maturity Rating (SMR) staging of sexual development, also known as Tanner
staging, provides a means of discretely documenting a child's progression through puberty …

Over the past 20 years, naturally occurring mutations that affect G protein-coupled receptors
(GPCRs) have been identified, mainly in patients with endocrine diseases. The study of loss …

Background: Kisspeptin peptides are critical in human reproductive physiology and are
potential therapies for infertility. Kisspeptin-10 stimulates gonadotropin release in both male …

Context: The G protein-coupled receptor 54 (GPR54), the kisspeptin receptor, is essential for
stimulation of GnRH secretion and induction of puberty. Recently loss-of-function mutations …

Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis manifests as
gonadotropin-dependent precocious puberty. The mechanisms behind HPG activation are …

Metastatic melanoma is a fatal disease due to the lack of successful therapies and
biomarkers for early detection and its incidence has been increasing. Genetic studies have …