Reactive oxygen and nitrogen species (ROS/RNS) are involved in numerous aspects of
cellular signaling. Classically ROS/RNS have been associated with cellular dysfunction and …

Neuronal nitric oxide synthases (nNOS) are Ca 2+/calmodulin-activated enzymes that
synthesize the gaseous messenger nitric oxide (NO). nNOSμ and the recently described …

Defective coupling between sarcoplasmic reticulum and mitochondria during control of
intracellular Ca 2+ signaling has been implicated in the progression of neuromuscular …

Calcium ions play fundamental roles in many cellular processes in virtually all type of cells.
The use of Ca 2+ sensitive fluorescent indicators has proven to be an indispensable tool for …

The type 1 isoform of the ryanodine receptor (RYR1) is the Ca2+ release channel of the
sarcoplasmic reticulum (SR) that is activated during skeletal muscle excitation–contraction …

Efficient intracellular Ca2+ ([Ca2+] i) homeostasis in skeletal muscle requires intact triad
junctional complexes comprised of t-tubule invaginations of plasma membrane and terminal …

Muscle contraction requires ATP and Ca2+ and, thus, is under direct control of mitochondria
and the sarcoplasmic reticulum. During postnatal skeletal muscle maturation, the …

The ryanodine receptor (RyR) calcium release channel is an essential intracellular ion
channel that is central to Ca2+ signaling and contraction in the heart and skeletal muscle …

We describe a novel transgenic system for tissue-specific and inducible control of gene
expression in mice. The system employs a tetracycline-responsive CMV promoter that …

Duchenne muscular dystrophy (DMD) is caused by a mutation of a single gene, dystrophin,
and is characterized by a slow progression and the increased turnover of myofiber …