Supply and demand for endocannabinoids

BE Alger, J Kim - Trends in neurosciences, 2011 - cell.com
The endocannabinoid system consists of G-protein-coupled cannabinoid receptors that can
be activated by cannabis-derived drugs and small lipids termed endocannabinoids (eCBs) …

Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain

CS Wu, CP Jew, HC Lu - Future neurology, 2011 - Taylor & Francis
Cannabis is the most commonly used illicit substance among pregnant women. Human
epidemiological and animal studies have found that prenatal cannabis exposure influences …

Brain cannabinoid CB2 receptors modulate cocaine's actions in mice

ZX Xi, XQ Peng, X Li, R Song, HY Zhang, QR Liu… - Nature …, 2011 - nature.com
The presence and function of cannabinoid CB2 receptors in the brain have been the
subjects of much debate. We found that systemic, intranasal or intra-accumbens local …

Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice

A Ortega-Alvaro, A Aracil-Fernández… - …, 2011 - nature.com
The possible role of the CB 2 receptor (CB 2 r) in psychiatric disorders has been considered.
Several animal models use knockout (KO) mice that display schizophrenia-like behaviors …

Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors

A Serrano, LH Parsons - Pharmacology & therapeutics, 2011 - Elsevier
The endogenous cannabinoid system is an important regulatory system involved in
physiological homeostasis. Endocannabinoid signaling is known to modulate neural …

Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight

V Di Marzo - Nature neuroscience, 2011 - nature.com
Studies of the endocannabinoid system in the CNS have been mostly focused on
endocannabinoid receptors and inactivating mechanisms. Until recently, very little was …

The multiplicity of action of cannabinoids: implications for treating neurodegeneration

A Gowran, J Noonan… - CNS neuroscience & …, 2011 - Wiley Online Library
The cannabinoid (CB) system is widespread in the central nervous system and is crucial for
controlling a range of neurophysiological processes such as pain, appetite, and cognition …

Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways

O Gomez, A Sanchez‐Rodriguez… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE The endogenous cannabinoid system participates in
oligodendrocyte progenitor differentiation in vitro. To determine the effect of synthetic …

Endocannabinoid-mediated synaptic plasticity and addiction-related behavior

N Sidhpura, LH Parsons - Neuropharmacology, 2011 - Elsevier
Endogenous cannabinoids (eCBs) are retrograde messengers that provide feedback
inhibition of both excitatory and inhibitory transmission in brain through the activation of …

Molecular model of cannabis sensitivity in developing neuronal circuits

E Keimpema, K Mackie, T Harkany - Trends in pharmacological sciences, 2011 - cell.com
Prenatal cannabis exposure can complicate in utero development of the nervous system.
Cannabis impacts the formation and functions of neuronal circuitries by targeting …