Brain metastases as preventive and therapeutic targets
PS Steeg, KA Camphausen, QR Smith - Nature Reviews Cancer, 2011 - nature.com
The incidence of metastasis to the brain is apparently rising in cancer patients and threatens
to limit the gains that have been made by new systemic treatments. The brain is considered …
to limit the gains that have been made by new systemic treatments. The brain is considered …
Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrier
LA Lampson - MAbs, 2011 - Taylor & Francis
Monoclonal antibodies (mAbs) are used with increasing success against many tumors but,
for brain tumors, the blood-brain barrier (BBB) is a special concern. The BBB prevents …
for brain tumors, the blood-brain barrier (BBB) is a special concern. The BBB prevents …
Trastuzumab
AH Boekhout, JH Beijnen, JHM Schellens - The oncologist, 2011 - academic.oup.com
Trastuzumab is standard of care in the treatment of human epidermal growth factor receptor
(HER)‐2+ early and advanced breast cancer. Recently, it has been approved for the …
(HER)‐2+ early and advanced breast cancer. Recently, it has been approved for the …
Risk of cardiac dysfunction with trastuzumab in breast cancer patients: a meta-analysis
T Chen, T Xu, Y Li, C Liang, J Chen, Y Lu, Z Wu… - Cancer treatment …, 2011 - Elsevier
BACKGROUND: Trastuzumab is used widely for the treatment of early and advanced breast
cancer. However, concerns have arisen regarding its cardiac toxicity. We did a systematic …
cancer. However, concerns have arisen regarding its cardiac toxicity. We did a systematic …
Multifactorial central nervous system recurrence susceptibility in patients with HER2‐positive breast cancer: Epidemiological and clinical data from a population …
A Musolino, L Ciccolallo, M Panebianco, E Fontana… - Cancer, 2011 - Wiley Online Library
BACKGROUND: A series of retrospective studies have reported that patients with human
epidermal growth factor receptor 2 (HER2)‐positive breast cancer are at a greater risk of …
epidermal growth factor receptor 2 (HER2)‐positive breast cancer are at a greater risk of …
I Diretriz Brasileira de cardio-oncologia da Sociedade Brasileira de Cardiologia
As doenças cardiovasculares nos pacientes com câncer são eventos cada vez mais
frequentes, em decorrência de avanços na terapêutica oncológica que resultaram tanto na …
frequentes, em decorrência de avanços na terapêutica oncológica que resultaram tanto na …
[HTML][HTML] Breast cancer subtypes and outcomes of central nervous system metastases
UY Arslan, B Oksuzoglu, S Aksoy, H Harputluoglu… - The Breast, 2011 - Elsevier
Central nervous system (CNS) metastases are detected in up to one third of patients with
advanced breast cancer, but their incidence and outcomes by breast cancer subtypes are …
advanced breast cancer, but their incidence and outcomes by breast cancer subtypes are …
Integrating Molecular Mechanisms and Clinical Evidence in the Management of Trastuzumab Resistant or Refractory HER‐2+ Metastatic Breast Cancer
H Wong, R Leung, A Kwong, J Chiu, R Liang… - The …, 2011 - academic.oup.com
Human epidermal growth factor receptor (HER)‐2+ breast cancer is a distinct molecular and
clinical entity, the prognosis of which is improved by trastuzumab. However, primary …
clinical entity, the prognosis of which is improved by trastuzumab. However, primary …
[HTML][HTML] Coping with uncertainty: T1a, bN0M0 HER2-positive breast cancer, do we have a treatment threshold?
CM Kelly, KI Pritchard, M Trudeau, E Andreopoulou… - Annals of oncology, 2011 - Elsevier
Background Recent retrospective studies have suggested that patients with T1a, bN0M0
human epidermal growth factor receptor 2 (HER2)-positive breast cancer are at a higher risk …
human epidermal growth factor receptor 2 (HER2)-positive breast cancer are at a higher risk …
Current neoadjuvant treatment options for HER2-positive breast cancer
H Abdel-Razeq, L Marei - Biologics: Targets and Therapy, 2011 - Taylor & Francis
Approximately one quarter of patients with breast cancer demonstrate amplification of the
human epidermal receptor type 2 (HER2) gene, the expression of which is associated with a …
human epidermal receptor type 2 (HER2) gene, the expression of which is associated with a …