AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …

AMP-activated protein kinase (AMPK) is a cellular energy sensor that exists in almost all
eukaryotes. Genetic studies in lower eukaryotes suggest that the ancestral role of AMPK was …

Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal
signals across multiple neuronal cell types. Here, we combine cell-type-specific …

Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that
cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer …

HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a
rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of …

Increased mitochondrial biogenesis by activation of PPAR-or AMPK/PGC-1α-dependent
homeostatic pathways has been proposed as a treatment for mitochondrial disease. We …

Tumor cell proliferation requires both growth signals and sufficient cellular bioenergetics.
The AMP-activated protein kinase (AMPK) pathway seems dominant over the oncogenic …

The mechanisms underlying the association between obesity and progressive renal disease
are not well understood. Exposure to a high-fat diet decreases levels of the cellular energy …

Neuropathic pain is a debilitating clinical condition with few efficacious treatments,
warranting development of novel therapeutics. We hypothesized that dysregulated …

AMPK is a ubiquitous sensor of cellular energy status in eukaryotic cells. It is activated by
stresses causing ATP depletion and, once activated, maintains energy homeostasis by …