Microfluidic approaches for gene delivery and gene therapy
Recent advances in microfluidics have created new and exciting prospects for gene delivery
and therapy. The micro-scaled environment within microfluidic systems enables precise …
and therapy. The micro-scaled environment within microfluidic systems enables precise …
Neural tissue engineering and biohybridized microsystems for neurobiological investigation in vitro (Part 1)
Advances in neural tissue engineering have resulted in the development and
implementation of three-dimensional (3-D) neural cellular constructs, which may serve as …
implementation of three-dimensional (3-D) neural cellular constructs, which may serve as …
A high-throughput microfluidic assay to study neurite response to growth factor gradients
Studying neurite guidance by diffusible or substrate bound gradients is challenging with
current techniques. In this study, we present the design, fabrication and utility of a …
current techniques. In this study, we present the design, fabrication and utility of a …
Device for co-culture of sympathetic neurons and cardiomyocytes using microfabrication
A Takeuchi, S Nakafutami, H Tani, M Mori… - Lab on a Chip, 2011 - pubs.rsc.org
Rat superior cervical ganglion (SCG) neurons and ventricular myocytes (VMs) were co-
cultured separately in a minichamber placed on a microelectrode-array (MEA) substrate …
cultured separately in a minichamber placed on a microelectrode-array (MEA) substrate …
Co‐pathological connected primary neurons in a microfluidic device for Alzheimer studies
A Kunze, R Meissner, S Brando… - Biotechnology and …, 2011 - Wiley Online Library
This communication presents a novel experimental model for Alzheimer studies, where
connected primary neurons were set into subtend, co‐pathological states. Cortical neurons …
connected primary neurons were set into subtend, co‐pathological states. Cortical neurons …
Manipulating location, polarity, and outgrowth length of neuron-like pheochromocytoma (PC-12) cells on patterned organic electrode arrays
In this manuscript, we describe a biocompatible organic electrode system, comprising poly
(3, 4-ethylenedioxythiophene)(PEDOT) microelectrode arrays on indium tin oxide (ITO) …
(3, 4-ethylenedioxythiophene)(PEDOT) microelectrode arrays on indium tin oxide (ITO) …
Microfluidic and compartmentalized platforms for neurobiological research
Methods to compartmentalize neurons allow distinct neuronal segments (ie, cell bodies,
axons, dendrites, or synapses) to be accessed, visualized, and/or manipulated …
axons, dendrites, or synapses) to be accessed, visualized, and/or manipulated …
Combined chemical and topographical guidance cues for directing cytoarchitectural polarization in primary neurons
AC Greene, CM Washburn, GD Bachand, CD James - Biomaterials, 2011 - Elsevier
Chemical and topographical cues can be used to guide dissociated neurons into user-
defined network geometries on artificial substrates, yet control of neuron polarity …
defined network geometries on artificial substrates, yet control of neuron polarity …
Pattern analysis and spatial distribution of neurons in culture
The nervous system is a complex, highly-ordered, integrated network of cells. Dispersed
cultures of neurons enable investigations into intrinsic cellular functions without the …
cultures of neurons enable investigations into intrinsic cellular functions without the …
Quantitative photochemical immobilization of biomolecules on planar and corrugated substrates: a versatile strategy for creating functional biointerfaces
TA Martin, CT Herman, FT Limpoco… - … applied materials & …, 2011 - ACS Publications
Methods for the generation of substratespresenting biomolecules in a spatially controlled
manner are enabling tools for applications in biosensor systems, microarray technologies …
manner are enabling tools for applications in biosensor systems, microarray technologies …