In this review we summarize current understanding of the development of autonomic
neurons in vertebrates. The mechanisms controlling the development of sympathetic and …

Studies in the area of human brain development are critical as research on neurological and
psychiatric disorders has advanced, revealing the origins of pathophysiology to be in the …

Methods: Retrospective review of children with HD after CS cared for using a systematic
algorithm at a tertiary care center. Potential anatomic etiologies were evaluated for first …

Abstract Background and Aims Researchers have not clearly described the clinical and
pathogenetic features of hypoganglionosis and adult-onset Hirschsprung's disease, which …

To facilitate dynamic imaging of neural crest (NC) lineages and discrimination of individual
cells in the enteric nervous system (ENS) where close juxtaposition often complicates …

Mitochondrial dysfunction is a central mediator of disease progression in diverse
neurodegenerative diseases that often present with prominent gastrointestinal …

Currently available therapies for gastrointestinal motility conditions are often inadequate.
Recent scientific advances, however, have facilitated the identification of neural stem cells …

The enteric nervous system (ENS) regulates peristaltic movement of the gut, and abnormal
ENS causes Hirschsprung's disease (HSCR) in newborns. HSCR is a congenital complex …

Background Hirschsprung's disease (HSCR) is a classic oligogenic disorder. Except
inactivating mutations of RET, some single nucleotide polymorphisms (SNPs) are identified …

La enfermedad de Hirschsprung (HSCR) es un desorden congénito caracterizado por la
ausencia de células ganglionares a lo largo del tracto gastrointestinal. Está causada por …