When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …

Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17)
cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F …

Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving
immune responses impacted our understanding of periodontitis? J Clin Periodontol 2011; …

Abstract Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, p19
and p40. The p40 subunit is shared with IL-12. IL-23 and IL-12 have different receptors and …

Abstract A20 (TNFAIP3) is a protein that is involved in the negative feedback regulation of
NF-κB signaling in response to specific proinflammatory stimuli in different cell types and …

Eur J Clin Invest 2011; 41 (12): 1361–1366 Abstract Background Inflammatory diseases are
linked to enhanced bone loss. The effect of inflammation on bone is mediated by …

Periodontitis is an infection characterized by the occurrence of supporting tissue destruction
with an episodic nature. Disease progression is often determined by the loss of attachment …

Since their identification in 2005, T helper (Th) 17 cells have been proposed to play
important roles in several human diseases, including various autoimmune conditions …

Fracture healing is a unique biologic process starting with an initial inflammatory response.
As in other regenerative processes, bone and the immune system interact closely during …

IL-17 cytokine family, though still young since discovery, has recently emerged as critical
players in immunity and inflammatory diseases. The prototype cytokine, IL-17A, plays …