Skeletal muscle continuously adapts to changes in its mechanical environment through
modifications in gene expression and protein stability that affect its physiological function …

Muscular dystrophies are genetically diverse but share common phenotypic features of
muscle weakness, degeneration, and progressive decline in muscle function. Previous work …

Repair of plasma membrane tears is an important normal physiological process that enables
the cells to survive a variety of physiological and pathological membrane lesions. Dysferlin …

Myoblast fusion contributes to muscle growth in development and during regeneration of
mature muscle. Myoblasts fuse to each other as well as to multinucleate myotubes to …

Background Mutations in the genes coding for either dystrophin or dysferlin cause distinct
forms of muscular dystrophy. Dystrophin links the cytoskeleton to the sarcolemma through …

Intermediate filaments, composed of desmin and of keratins, play important roles in linking
contractile elements to each other and to the sarcolemma in striated muscle. Our previous …

Dysferlinopathies are autosomal recessive disorders caused by mutations in the dysferlin
(DYSF) gene, encoding the dysferlin protein. DYSF mutations lead to a wide range of …

Mutations in the DYSF gene that severely reduce the levels of the protein dysferlin are
implicated in muscle-wasting syndromes known as dysferlinopathies. Although studies of its …

Muscle strains are one of the most common complaints treated by physicians. A muscle
injury is typically diagnosed from the patient history and physical exam alone, however the …

Electroporation (EP) is used to transfect skeletal muscle fibers in vivo, but its effects on the
structure and function of skeletal muscle tissue have not yet been documented in detail. We …