The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …

Among people exposed to major psychological stressors in early life, there are elevated
rates of morbidity and mortality from chronic diseases of aging. The most compelling data …

Neutrophils have long been viewed as the final effector cells of an acute inflammatory
response, with a primary role in the clearance of extracellular pathogens. However, more …

There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective
effect on human health. Identifying bioactive dietary constituents is an active area of …

Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a
multi-step process which includes local tumor cell invasion, entry into the vasculature …

Objective: To examine the long-term oncological impact of anastomotic leakage (AL) after
restorative surgery for colorectal cancer using meta-analytical methods. Outcomes …

Excessive or inappropriate activation of the immune system can be deleterious to the
organism, warranting multiple molecular mechanisms to control and properly terminate …

Members of the tumour necrosis factor (TNF) receptor superfamily have important functions
in immunity and inflammation. Recently linear ubiquitin chains assembled by a complex …

Metagenomic approaches are currently being used to decipher the genome of the
microbiota (microbiome), and, in parallel, functional studies are being performed to analyze …