Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

Although lung cancer remains the leading cancer killer in the United States, recently a
number of developments indicate future clinical benefit. These include evidence that …

Introduction: Lung cancer and COPD commonly coexist in smokers, and the presence of
COPD increases the risk of developing lung cancer. In addition to smoking cessation and …

Background Lung cancer is the leading cause of cancer-related death worldwide. Genetic
and epigenetic alterations have been identified frequently in lung cancer, such as promoter …

Introduction: Cancer treatment is moving away from conventional cytotoxic drugs and
towards agents that target specific proteins important to cancer development or survival. The …

Rationale: Autofluorescence bronchoscopy (AFB) is a valid strategy for detecting
premalignant endobronchial lesions. However, no biomarker can reliably predict lung …

Recent studies have demonstrated the significance of the leukemia oncogene Evi1 as the
regulator of hematopoietic stem cells and marker of poor clinical outcomes in myeloid …

Phosphatidylinositol 3-kinases (PI3Ks) are key molecules in the signal transduction
pathways initiated by the binding of extracellular signals to their cell surface receptors. The …

Abstract The 14‐3‐3 proteins are a set of seven highly conserved proteins that have recently
been implicated in having a role in human tumorigenesis. However, the mechanism by …

Inappropriate PI3K signaling is one of the most frequent occurrences in human cancer and
is critical for tumor progression. A variety of genetic mutations and amplifications have been …