Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

HK Makadia, SJ Siegel - Polymers, 2011 - mdpi.com
In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive
polymeric candidates used to fabricate devices for drug delivery and tissue engineering …

Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy?

VT Tran, JP Benoît, MC Venier-Julienne - International journal of …, 2011 - Elsevier
Drug delivery via biodegradable microparticles benefits from both the protection of the
encapsulated drug from hazardous conditions and the controlled release of the …

[HTML][HTML] Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus

M Yang, SK Lai, YY Wang, W Zhong… - … (International ed. in …, 2011 - ncbi.nlm.nih.gov
Mucus is a highly viscoelastic and adhesive substance that protects against infection and
injury at nearly all entry points to the body not covered by skin. However, mucus also traps …

A Strategy for Control of “Random” Copolymerization of Lactide and Glycolide: Application to Synthesis of PEG-b-PLGA Block Polymers Having Narrow Dispersity

H Qian, AR Wohl, JT Crow, CW Macosko… - Macromolecules, 2011 - ACS Publications
Poly (lactic-co-glycolic acid)(PLGA) is a biodegradable copolymer that is also acceptable for
use in a variety of biomedical applications. Typically, a random PLGA polymer is …

Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior

V Karavelidis, E Karavas, D Giliopoulos… - International Journal …, 2011 - Taylor & Francis
Four new polyesters based on 1, 3-propanediol and different aliphatic dicarboxylic acids
were used to prepare ropinirole HCl-loaded nanoparticles. The novelty of this study lies in …

A multiplexed electrospray process for single-step synthesis of stabilized polymer particles for drug delivery

B Almería, TM Fahmy, A Gomez - Journal of controlled release, 2011 - Elsevier
While conventional methods for biodegradable particle production rely predominately on
batch, emulsion preparation methods, an alternative process based on multiplexed …

Precise synthesis of molecularly defined oligomers and polymers by orthogonal iterative divergent/convergent approaches

S Binauld, D Damiron, LA Connal… - Macromolecular …, 2011 - Wiley Online Library
The synthesis of perfectly defined (macro) molecules has been a constant challenge for
polymer and organic chemists. This paper highlights the main applications of the iterative …

Nanoparticulate systems for drug delivery and targeting to the central nervous system

EF Craparo, ML Bondì, G Pitarresi… - CNS neuroscience & …, 2011 - Wiley Online Library
Brain delivery is one of the major challenges for the neuropharmaceutical industry since an
alarming increase in brain disease incidence is going on. Despite major advances in …

Intracellular degradation and distribution of protein-encapsulated amphiphilic poly (amino acid) nanoparticles

T Akagi, F Shima, M Akashi - Biomaterials, 2011 - Elsevier
Physicochemical properties, such as particle size, shape, molecular weight, surface charge
and composition, play a key role in the cellular uptake of polymeric nanoparticles. Antigen …

Biodegradable polymeric microcapsules: Preparation and properties

H Sawalha, K Schroën, R Boom - Chemical engineering journal, 2011 - Elsevier
Biodegradable polymeric microcapsules can be produced through different methods of
which emulsion solvent-evaporation/extraction is frequently used. In this technique, the …