The heart is responsible for pumping blood throughout the blood vessels to the periphery by
repeated, rhythmic contractions at variable intensity. As such the heart should permanently …

van Spaendonck‐Zwarts KY, van Hessem L, Jongbloed JDH, de Walle HEK, Capetanaki Y,
van der Kooi AJ, van Langen IM, van den Berg MP, van Tintelen JP. Desmin‐related …

Backround Radiation therapy treatment of breast cancer, Hodgkin's disease or childhood
cancers expose the heart to high local radiation doses, causing an increased risk of …

The aim of the present study was to define the chronic effects of neuromuscular electrical
stimulation (NMES) on the neuromuscular properties of human skeletal muscle. Eight young …

Interactions with vimentin intermediate filaments (VimIFs) affect the motility, distribution, and
anchorage of mitochondria. In cells lacking VimIFs or in which VimIF organization is …

Muscle contraction relies on a highly organized intracellular network of membrane
organelles and cytoskeleton proteins. Among the latter are the intermediate filaments (IFs), a …

Chronic anthracycline cardiotoxicity is a feared complication of cancer chemotherapy.
However, despite several decades of primarily hypothesis-driven research, the molecular …

In ectotherms, the external temperature is experienced by the mitochondria, and the
mitochondrial respiration of different genotypes is likely to change as a result. Using high …

Intermediate filaments, composed of desmin and of keratins, play important roles in linking
contractile elements to each other and to the sarcolemma in striated muscle. Our previous …

Volume overload (VO) caused by aortocaval fistula (ACF) is associated with
oxidative/inflammatory stress. The resulting inflammation, matrix metalloproteinase (MMP) …