Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the
earliest arrivals at target organs of disease. However, the role of NK cells in mounting …

Controversy exists as to the role that the immune system plays in cancer therapy. While the
immune system has been proposed to scavenge the body to prevent microscopic …

Abstract Interferon-α (IFN-α), a type I IFN, is a well-known antitumoral agent. The
investigation of its clinical properties in acute myeloid leukemia (AML) has been prompted …

Background Cystic echinococcosis is a worldwide distributed helminth zoonosis caused by
the larval stage of Echinococcus granulosus. Human secondary cystic echinococcosis is …

The distinct feature of hepatitis C virus (HCV) infection is a high incidence of chronicity. The
reason for chronic HCV infection has been actively investigated, and impairment of innate …

A void in understanding primary biliary cirrhosis (PBC) is the absence of appropriate animal
models. Our laboratory has studied a murine model of autoimmune cholangitis induced …

α Active specific immunotherapy aims at stimulating the host's immune system to recognize
and eradicate malignant cells. The concomitant activation of dendritic cells (DC) and natural …

Rare human primary immunodeficiency disorders with extreme susceptibility to infections in
infancy have provided important insights into immune function. Increasingly, however …

NK cells in the lymph nodes play important roles in inhibiting tumor metastasis into draining
lymph nodes. Previously, we reported that chronic alcohol consumption interferes with NK …

NK cells are multicompetent lymphocytes of the innate immune system with a central role in
host defense and immune regulation. Studies in experimental animal models of multiple …