Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

The role of metabolites and metabolomics in clinically applicable biomarkers of disease

M Mamas, WB Dunn, L Neyses, R Goodacre - Archives of toxicology, 2011 - Springer
Metabolomics allows the simultaneous and relative quantification of thousands of different
metabolites within a given sample using sensitive and specific methodologies such as gas …

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

WB Dunn, D Broadhurst, P Begley, E Zelena… - Nature protocols, 2011 - nature.com
Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

[PDF][PDF] 'Omic'technologies: genomics, transcriptomics, proteomics and metabolomics.

RP Horgan, LC Kenny - Obstetrician & Gynaecologist, 2011 - researchgate.net
'Omic'technologies adopt a holistic view of the molecules that make up a cell, tissue or
organism. They are aimed primarily at the universal detection of genes (genomics), mRNA …

Non-invasive phenotyping using exhaled volatile organic compounds in asthma

B Ibrahim, M Basanta, P Cadden, D Singh, D Douce… - Thorax, 2011 - thorax.bmj.com
Background Breath volatile organic compounds (VOCs) may be useful for asthma diagnosis
and phenotyping, identifying patients who could benefit from personalised therapeutic …

An integrated approach to characterize genetic interaction networks in yeast metabolism

B Szappanos, K Kovács, B Szamecz, F Honti… - Nature …, 2011 - nature.com
Although experimental and theoretical efforts have been applied to globally map genetic
interactions, we still do not understand how gene-gene interactions arise from the operation …

The relationship among sexual attitudes, sexual fantasy, and religiosity

TK Ahrold, M Farmer, PD Trapnell… - Archives of sexual behavior, 2011 - Springer
Recent research on the impact of religiosity on sexuality has highlighted the role of the
individual, and suggests that the effects of religious group and sexual attitudes and fantasy …

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

M Brown, DC Wedge, R Goodacre, DB Kell… - …, 2011 - academic.oup.com
Motivation: The study of metabolites (metabolomics) is increasingly being applied to
investigate microbial, plant, environmental and mammalian systems. One of the limiting …

Portraying real science in science communication

EM Dijk - Science Education, 2011 - Wiley Online Library
In both formal and informal settings, not only science but also views on the nature of science
are communicated. Although there probably is no singular nature shared by all fields of …

Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy

RP Horgan, DI Broadhurst, SK Walsh… - Journal of proteome …, 2011 - ACS Publications
Being born small for gestational age (SGA) confers increased risks of perinatal morbidity
and mortality and increases the risk of cardiovascular complications and diabetes in later …