Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs
PE Almeida Da Silva… - Journal of antimicrobial …, 2011 - academic.oup.com
Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …
[HTML][HTML] Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism
ST Thomas, BC VanderVen, DR Sherman… - Journal of Biological …, 2011 - ASBMB
Mycobacterium tuberculosis, the bacterium that causes tuberculosis, imports and
metabolizes host cholesterol during infection. This ability is important in the chronic phase of …
metabolizes host cholesterol during infection. This ability is important in the chronic phase of …
[HTML][HTML] The Bacillus anthracis arylamine N-acetyltransferase ((BACAN) NAT1) that inactivates sulfamethoxazole, reveals unusual structural features compared with …
B Pluvinage, IL de la Sierra-Gallay, X Kubiak, X Xu… - FEBS letters, 2011 - Elsevier
Arylamine N-acetyltransferases (NATs) are xenobiotic-metabolizing enzymes that
biotransform arylamine drugs. The Bacillus anthracis (BACAN) NAT1 enzyme affords …
biotransform arylamine drugs. The Bacillus anthracis (BACAN) NAT1 enzyme affords …
Improvement of the expression and purification of Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) a potential target for novel anti-tubercular …
A Abuhammad, N Lack, J Schweichler… - Protein Expression and …, 2011 - Elsevier
Arylamine N-acetyltransferase from Mycobacterium tuberculosis (TBNAT) has been
proposed as a drug target for latent tuberculosis treatment. The enzyme is essential for the …
proposed as a drug target for latent tuberculosis treatment. The enzyme is essential for the …
[HTML][HTML] New N-acetyltransferase fold in the structure and mechanism of the phosphonate biosynthetic enzyme FrbF
B Bae, RE Cobb, MA DeSieno, H Zhao… - Journal of Biological …, 2011 - ASBMB
The enzyme FrbF from Streptomyces rubellomurinus has attracted significant attention due
to its role in the biosynthesis of the antimalarial phosphonate FR-900098. The enzyme …
to its role in the biosynthesis of the antimalarial phosphonate FR-900098. The enzyme …
Host expression of methylmalonyl-CoA mutase and tuberculosis: A missing link?
Bovine tuberculosis (bTB) is a disease caused by Mycobacterium bovis and closely related
species of the Mycobacterium tuberculosis complex. bTB is an important health problem …
species of the Mycobacterium tuberculosis complex. bTB is an important health problem …
Characterization of an oxidoreductase from the arylamine N‐acetyltransferase operon in Mycobacterium smegmatis
D Evangelopoulos, N Cronin, T Daviter, E Sim… - The FEBS …, 2011 - Wiley Online Library
Mycobacterium tuberculosis, the most successful bacterial pathogen, causes tuberculosis, a
disease that still causes more than 2 million deaths per year. Arylamine N‐acetyltransferase …
disease that still causes more than 2 million deaths per year. Arylamine N‐acetyltransferase …