The immunogenic heat shock proteins (HSPs) gp96, hsp70 and calreticulin (CRT) bind to
CD91 on antigen-presenting cells (APCs) for cross-presentation of the HSP-chaperoned …

Heat shock proteins are ubiquitously expressed intracellular proteins and act as molecular
chaperones in processes like protein folding and protein trafficking between different …

Purpose: We previously reported that autophagy in tumor cells plays a critical role in cross-
presentation of tumor antigens and that autophagosomes are efficient antigen carriers for …

Abstract Heat shock protein 70 (Hsp70) is a powerful chaperone whose expression is
induced in response to a wide variety of physiological and environmental insults, including …

Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity.
Many of these effects are mediated by cell surface receptors expressed on a wide range of …

Vaccination immunotherapies offer the promise of long-term tumor control, and preclinical
trials have found promising results. Active immunotherapy uses the adaptive immune …

Efforts to develop a subunit vaccine against genital herpes have been hampered by lack of
knowledge of the protective antigens of HSV-2, the causative agent of the disease. Vaccines …

One of the main issues in vaccine development is implementation of new adjuvants to
improve the antigen presentation and eliciting the protective immune response. Heat shock …

We previously reported that scavenger receptor A (SRA/CD204), a binding structure on
dendritic cells (DCs) for large stress/heat shock proteins (HSPs; eg, hsp110 and grp170) …

Binding of immunoglobulin protein (BiP) is a major molecular chaperone localized in
endoplasmic reticulum (ER). It has been demonstrated to interact with nascent Ig. However …