Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia.
It can linger for many years, but ultimately is fatal, the 6th leading cause of death …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
insidious cognitive decline and memory dysfunction. Synapse loss is the best pathological …

In Alzheimer's disease (AD), dementia severity correlates strongly with decreased synapse
density in hippocampus and cortex. Numerous studies report that hippocampal long-term …

A role for PrP in the toxic effect of oligomeric forms of Aβ, implicated in Alzheimer's disease
(AD), has been suggested but remains controversial. Here we show that PrP is required for …

Some of the most prevalent human degenerative diseases appear as a result of the
misfolding and aggregation of proteins. Compelling evidence suggest that misfolded protein …

Lipid rafts are membrane microdomains, enriched in cholesterol and sphingolipids, into
which specific subsets of proteins and lipids partition, creating cell‐signalling platforms that …

Pyroglutamate-modified amyloid-β (Aβ pE3) peptides are gaining considerable attention as
potential key participants in the pathology of Alzheimer disease (AD) due to their abundance …

The molecular chaperone αB-crystallin is a small heat-shock protein that is upregulated in
response to a multitude of stress stimuli, and is found colocalized with Aβ amyloid fibrils in …

Aβ oligomers cause a collection of molecular events associated with memory loss in
Alzheimer's disease, centering on disrupting the maintenance of synapse structure and …

Alzheimer's disease (AD) is a neurodegenerative disorder occurring in the elderly. It is
widely accepted that the amyloid beta peptide (Aβ) aggregation and especially the …