Wnt signaling during synaptic development and plasticity

V Budnik, PC Salinas - Current opinion in neurobiology, 2011 - Elsevier
The formation of synaptic connections requires a dialogue between pre and postsynaptic
cells to coordinate the assembly of the presynaptic release machinery and the postsynaptic …

Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca2+/Calmodulin-dependent protein kinase II

L Ciani, KA Boyle, E Dickins… - Proceedings of the …, 2011 - National Acad Sciences
The balance between excitatory and inhibitory synapses is crucial for normal brain function.
Wnt proteins stimulate synapse formation by increasing synaptic assembly. However, it is …

Regulation of NMDA-receptor synaptic transmission by Wnt signaling

W Cerpa, A Gambrill, NC Inestrosa… - Journal of …, 2011 - Soc Neuroscience
Wnt ligands are secreted glycoproteins controlling gene expression and cytoskeleton
reorganization involved in embryonic development of the nervous system. However, their …

Wnt5a is a cell-extrinsic factor that supports self-renewal of mouse spermatogonial stem cells

JR Yeh, X Zhang, MC Nagano - Journal of cell science, 2011 - journals.biologists.com
The maintenance of spermatogonial stem cells (SSCs) provides the foundation for life-long
spermatogenesis. Although glial-cell-line-derived neurotrophic factor and fibroblast growth …

[HTML][HTML] Synaptic Wnt signaling—a contributor to major psychiatric disorders?

ND Okerlund, BNR Cheyette - Journal of neurodevelopmental disorders, 2011 - Springer
Wnt signaling is a key pathway that helps organize development of the nervous system. It
influences cell proliferation, cell fate, and cell migration in the developing nervous system …

Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway

EW Bradley, MH Drissi - Journal of cellular physiology, 2011 - Wiley Online Library
Although genetic evidence has demonstrated a role for Wnt5b during cartilage and limb
development, little is known about the mechanisms underlying Wnt5b‐regulated …

Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo

S Paina, D Garzotto, S DeMarchis… - Journal of …, 2011 - Soc Neuroscience
During brain development, neurogenesis, migration, and differentiation of neural progenitor
cells are regulated by an interplay between intrinsic genetic programs and extrinsic cues …

Activity-Mediated Synapse Formation: A Role for Wnt-Fz Signaling

M Sahores, PC Salinas - Current topics in developmental biology, 2011 - Elsevier
Synapse formation is a critical step in the assembly of neuronal circuits. Both secreted and
membrane-associated proteins contribute to the assembly and maturation of synapses. In …

NMDA 受体激活引起的突触活动对Wnt 非经典通路的影响

李屹晨, 万仙子, 杨湘玲, 杨成, 张薇, 钟翎 - 中国实验动物学报, 2011 - cqvip.com
目的探讨NMDA 受体激活引起的突触活动诱导Wnt 非经典通路的活化. 方法构建C57BL/6J
胎鼠大脑皮层神经元原代培养体系, 用NMDA 处理神经元细胞, 并结合Western blotting …

异丙酚对新生大鼠海马突触后致密物-95 和突触素表达的影响

陶虓嫣, 唐小曼, 谢玉波 - 广东医学, 2011 - cqvip.com
目的观察异丙酚对新生大鼠海马突触后致密物-95 (PSD-95) 和突触素mRNA 表达的影响.
方法雄性SD 大鼠30 只, 日龄7 d, 体重10~ 15 g, 随机分为对照组和异丙酚组, 每组15 只 …