Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory syndrome involving the
biliary tract, often accompanied by inflammatory bowel disease (IBD). This syndrome is a …

Background Primary sclerosing cholangitis is a progressive chronic cholestatic liver disease
that usually leads to the development of cirrhosis. Studies evaluating bile acids in the …

BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease
associated with increased morbidity and mortality. Ursodeoxycholic acid (UDCA) may have …

OBJECTIVES: Some studies have suggested that ursodeoxycholic acid (UDCA) may have a
chemopreventive effect on the development of colorectal neoplasia in patients with …

Aliment Pharmacol Ther 2011; 34: 901–910 Summary Background There is no satisfactory
medical treatment for patients with primary sclerosing cholangitis. There are conflicting data …

Hintergrund Die Colitis ulcerosa (CU) ist neben dem Morbus Crohn die wichtigste chronisch-
entzündliche Darmerkrankung (CED). Die Inzidenz für die Colitis ulcerosa liegt in …

Autoimmune liver disorders in childhood include autoimmune hepatitis, autoimmune
sclerosing cholangitis and de novo autoimmune hepatitis after liver transplant. These …

Background Primary sclerosing cholangitis (PSC) remains a challenging disease to
manage. The main goals are prevention of disease progression and reduction of the …

Non-alcoholic steatohepatitis (NASH) is estimated to affect about 1% of the European and
North-American population. Longitudinal studies reported that the histological parameters …

Tight junctions between hepatocytes and cholangiocytes play a fundamental role in
separating bile flow from plasma. Secondary alterations of tight junctions are well described …