Microglia—resident myeloid-lineage cells in the brain and the spinal cord parenchyma—
function in the maintenance of normal tissue homeostasis. Microglia also act as sentinels of …

The diseased brain hosts a heterogeneous population of myeloid cells, including
parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne …

In multiple sclerosis and the experimental autoimmune encephalitis (EAE) mouse model,
two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory …

HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5
or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral …

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of
the brain is restricted by brain barriers, of which the most well known are the blood–brain …

Cell-based therapies are fast-growing forms of personalized medicine that make use of the
steady advances in stem cell manipulation and gene transfer technologies. In this Review, I …

Microglia, the resident immune cells of the mammalian central nervous system (CNS), play a
pivotal role in both physiological and pathological conditions such as the restoration of CNS …

Mononuclear phagocytes are important modulators of Alzheimer9s disease (AD), but the
specific functions of resident microglia, bone marrow-derived mononuclear cells, and …

The infiltration of leukocytes into the central nervous system (CNS) is an essential step in the
neuropathogenesis of multiple sclerosis (MS). Leukocyte extravasation from the …

Microglia are immunocompetent cells of the brain that continuously survey their environment
with highly motile extensions. Although first described almost a century ago, the …