p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human
cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of …

Childhood neuroblastoma exhibits a heterogeneous clinical behavior ranging from low-risk
tumors with the ability to spontaneously differentiate and regress, to high-risk tumors causing …

p73 is a tumor suppressor belonging to the p53 family of transcription factors. Distinct
isoforms are transcribed from the p73 locus. The use of 2 promoters at the N-terminus allows …

p53 is one of the most studied tumor suppressors in the cancer research field. Of note, over
50% of human tumors carry loss of function mutations, and thus p53 has been considered to …

Resveratrol is a naturally occurring trihydroxyl-diphenylethylene compound that has been
shown experimentally to have beneficial effects in the treatment of cancer and …

The human p53 tumour suppressor protein is inactivated in many cancers and is also a
major player in apoptotic responses to cellular stress. The p53 protein and the two other …

Cancer stem-like cells (CSCs) possessing features of neural precursor cells (NPC) influence
initiation, recurrence and chemoresistance of glioblastoma multiforme (GBM). As …

Epidemiologic and clinical evidence points to an increased risk for cancer when coupled
with chronic inflammation. However, the molecular mechanisms that underpin this …

The activation and regulation of target genes by the tumour-suppressor p53 dictates the fate
of a cell, with cell cycle arrest or apoptosis being two distinct outcomes. PERP (p53 …

Loss of p53 function can occur through disruption of its ability to localize to the nucleus.
Previously we showed through characterization a set of mutant cell lines that lacked the …