Over the past two decades it became evident that the immune system plays a central role in
modulating learning, memory and neural plasticity. Under normal quiescent conditions …

PURPOSE: To review findings from major epidemiologic studies regarding risk factors for
and consequences of elevated markers of inflammation in older adults. RESULTS: Most …

Background A large body of research has focused on “mediating mechanisms” and
predisposing brain abnormalities to geriatric depression, but little is known about its etiology …

Antidepressants, predominantly serotonin-and/or noradrenaline reuptake inhibiting drugs
have several shortcomings. The exact pathophysiological mechanisms leading to …

Caloric restriction (CR) causes a reduction in body temperature (Tb) which is suggested to
contribute to changes that increase lifespan. Moreover, low Tb has been shown to improve …

We tested the hypothesis that peripheral blood mononuclear cells (PBMC) of older adults
demonstrate a proinflammatory/-oxidative gene expression profile that can be improved by …

In this chapter we describe changes in the immune system that are thought to be related to
age per se. We subsequently review the clinical implications of these changes, including the …

Dermal connective tissue collagen is the major structural protein in skin. Fibroblasts within
the dermis are largely responsible for collagen production and turnover. We have previously …

Hormones regulate growth, development, metabolism, and other complex processes in
multicellular animals. For many years it has been suggested that hormones may also …

The cause of geriatric depression is not well understood. Attempts to identify causes that
contribute to geriatric depression have focused on the role of its comorbid disorders and on …