Design, synthesis, and validation of a β-turn mimetic library targeting protein–protein and peptide–receptor interactions
LR Whitby, Y Ando, V Setola, PK Vogt… - Journal of the …, 2011 - ACS Publications
The design and synthesis of a β-turn mimetic library as a key component of a small-molecule
library targeting the major recognition motifs involved in protein–protein interactions is …
library targeting the major recognition motifs involved in protein–protein interactions is …
Design, synthesis, pharmacological evaluation, and structure− activity study of novel endomorphin analogues with multiple structural modifications
This study reports on new proteolytically stable, pharmacologically active endomorphin
analogues, incorporating Dmt1, Achc2, p FPhe4, or βMePhe4 unnatural amino acids …
analogues, incorporating Dmt1, Achc2, p FPhe4, or βMePhe4 unnatural amino acids …
Phe-Ala-based diazaspirocyclic lactam as nucleator of type II′ β-turn
A Sacchetti, A Silvani, G Lesma… - The Journal of Organic …, 2011 - ACS Publications
The synthesis of a novel Phe-Ala dipeptide mimic, built up on a diazaspirocyclic lactam core,
is presented. This new scaffold was evaluated for conformational mimicry of reverse turn by …
is presented. This new scaffold was evaluated for conformational mimicry of reverse turn by …
Asymmetric Synthesis and Conformational Analysis by NMR Spectroscopy and MD of Aba‐and α‐MeAba‐Containing Dermorphin Analogues
B Vandormael, R De Wachter, JC Martins… - …, 2011 - Wiley Online Library
Dermorphin analogues, containing a (S)‐and (R)‐4‐amino‐1, 2, 4, 5‐tetrahydro‐2‐
benzazepin‐3‐one scaffold (Aba) and the α‐methylated analogues as conformationally …
benzazepin‐3‐one scaffold (Aba) and the α‐methylated analogues as conformationally …