Pharmacogenetics of antidepressant response
Personalized medicine—the adaptation of therapies based on an individual's genetic and
molecular profile—is one of the most promising aspects of modern medicine. The …
molecular profile—is one of the most promising aspects of modern medicine. The …
Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective
J Waider, N Araragi, L Gutknecht, KP Lesch - Psychoneuroendocrinology, 2011 - Elsevier
Based on genetic variation, there is accumulating evidence that altered function of
tryptophan hydroxylase-2 (TPH2), the enzyme critical for synthesis of serotonin (5-HT) in the …
tryptophan hydroxylase-2 (TPH2), the enzyme critical for synthesis of serotonin (5-HT) in the …
Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia
The present study is aimed at exploring whether some single nucleotide polymorphisms
(SNPs) within the tryptophan hydroxylase 2 gene (TPH2) could be associated with major …
(SNPs) within the tryptophan hydroxylase 2 gene (TPH2) could be associated with major …
Diurnal variations in depression-like behavior of Wistar and spontaneously hypertensive rats in the kainate model of temporal lobe epilepsy
J Tchekalarova, D Pechlivanova, T Atanasova… - Epilepsy & Behavior, 2011 - Elsevier
The purpose of this study was to explore whether the kainate (KA) model of temporal lobe
epilepsy (TLE) can be used as a model of comorbid epilepsy and depression to study …
epilepsy (TLE) can be used as a model of comorbid epilepsy and depression to study …
Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains
Chronic stress and alterations in the serotonergic system are key predisposing factors to the
development of major depression. Tryptophan hydroxylase (TPH) is the key enzyme in the …
development of major depression. Tryptophan hydroxylase (TPH) is the key enzyme in the …
Exploring epistasis in candidate genes for antisocial personality disorder
JMC Arias, CAP Acosta, JG Valencia… - Psychiatric …, 2011 - journals.lww.com
Objective To identify and characterize high-order gene-to-gene interactions in antisocial
personality disorder (ASPD). Methods Participants for case–control study were selected from …
personality disorder (ASPD). Methods Participants for case–control study were selected from …
Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome
S Jun, R Kohen, KC Cain, ME Jarrett… - …, 2011 - Wiley Online Library
Background Alterations in serotonin (5HT) are suspected in the pathophysiology of irritable
bowel syndrome (IBS). Tryptophan hydroxylase (TPH) is the ratelimiting enzyme in the …
bowel syndrome (IBS). Tryptophan hydroxylase (TPH) is the ratelimiting enzyme in the …
TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients
HC Wang, TL Yeh, HH Chang, PW Gean, MH Chi… - …, 2011 - Springer
Abstract Rationale Tryptophan hydroxylase 1 (TPH1), which encodes the rate-limiting
enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the …
enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the …
Gender differences in tryptophan hydroxylase-2 mRNA, serotonin, and 5-hydroxytryptophan levels in the brain of catfish, Clarias gariepinus, during sex differentiation
K Raghuveer, CC Sudhakumari… - General and …, 2011 - Elsevier
Tryptophan hydroxylase (tph) is the key regulator in serotonin (5-HT) biosynthesis that
stimulates the release of GnRH and gonadotropins by acting at the level of hypothalamo …
stimulates the release of GnRH and gonadotropins by acting at the level of hypothalamo …
Development by environment interactions controlling tryptophan hydroxylase expression
Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin (5-
hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different …
hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different …