All tissues and organs can be classified according to their ability to repair and regenerate
during adult homeostasis and after injury. Some exhibit a high rate of constant cell turnover …

Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease characterised by alveolar
accumulation of surfactant. It may result from mutations in surfactant proteins or granulocyte …

Background The mutations that have been implicated in pulmonary fibrosis account for only
a small proportion of the population risk. Methods Using a genomewide linkage scan, we …

Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with
familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or …

A Variant in the Promoter of <italic>MUC5B</italic> and Idiopathic Pulmonary Fibrosis Page 1
n engl j med 364;16 nejm.org april 21, 2011 1576 The new england journal of medicine …

Endoplasmic reticulum (ER) stress has been implicated in alveolar epithelial type II (AT2)
cell apoptosis in idiopathic pulmonary fibrosis. We hypothesized that ER stress (either …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease of the lungs that
increases in prevalence with advanced age. Recent evidence indicates that mutations in …

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea, interstitial
infiltrates in lung parenchyma and restriction on pulmonary function testing. IPF is the most …

Mutations in genes encoding proteins needed for normal surfactant function and metabolism
cause acute lung disease in newborns and chronic lung disease in older children and …

Several mutations in the surfactant protein C (SP-C) gene (SFTPC) have been reported as
causing familial pulmonary fibrosis (FPF). However, the genetic background and clinical …