Background Chronic kidney disease (CKD) and end-stage renal disease (ESRD) represent
worldwide health problems with an epidemic extent. Therefore, attention must be given to …

Drug dosage adjustment for patients with acute or chronic kidney disease is an accepted
standard of practice. The challenge is how to accurately estimate a patient's kidney function …

Chronic kidney disease (CKD) is increasing at an alarming rate. Medication prescribing in
this growing population is especially difficult. Many pharmacological agents or their …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• In paediatric development, initial
estimation of the paediatric dose is obtained by extrapolation. This is usually performed …

The complexity of managing critically ill patients has increased since the early establishment
of intensive care units in the 1950s. Despite of the fact that the number of drugs available to …

Psychische Störungen bei somatischen Krankheiten definieren einen Kernsektor der
psychosomatischen Medizin. Kognitive wie affektive Veränderungen können gleichermaßen …

The management of hematological malignancies (HM) in renally impaired patients may be a
difficult task. Indeed, the kidney represents a major elimination pathway for many …

Objective Roflumilast is a novel, orally active, selective phosphodiesterase 4 inhibitor
recently approved in the European Union for the treatment of severe COPD. Roflumilast and …

Chronic kidney disease (CKD) has a high prevalence in the elderly. It has been recognized
as an independent cardiovascular risk factor and detecting CKD is also important to ensure …

BACKGROUND: Measurement of serum creatinine concentration is central to evaluation of
kidney function. Recent efforts to increase the accuracy of this evaluation have led to …