Sulfur mustard toxicity: history, chemistry, pharmacokinetics, and pharmacodynamics
Sulfur mustard (SM) and similar bifunctional agents have been used as chemical weapons
for almost 100 years. Victims of high-dose exposure, both combatants and civilians, may die …
for almost 100 years. Victims of high-dose exposure, both combatants and civilians, may die …
[HTML][HTML] PARP inhibitor treatment in ovarian and breast cancer
MK Weil, A Chen - Current problems in cancer, 2011 - ncbi.nlm.nih.gov
Poly (ADP-ribose) polymerase (PARP) inhibitors have raised recent excitement because of
the activity reported in triple negative breast cancer (TNBC) with iniparib (BSI 201)[1] and …
the activity reported in triple negative breast cancer (TNBC) with iniparib (BSI 201)[1] and …
ATM protein kinase: the linchpin of cellular defenses to stress
ATM is the most significant molecule involved in monitoring the genomic integrity of the cell.
Any damage done to DNA relentlessly challenges the cellular machinery involved in …
Any damage done to DNA relentlessly challenges the cellular machinery involved in …
The Phenotypic Radiation Resistance of CD44+/CD24−or low Breast Cancer Cells Is Mediated through the Enhanced Activation of ATM Signaling
H Yin, J Glass - PloS one, 2011 - journals.plos.org
Cancer initiating cells (CIC) are stem-like cells. CIC may contribute not only to the initiation
of cancer but also to cancer recurrence because of the resistance of CIC both to …
of cancer but also to cancer recurrence because of the resistance of CIC both to …
The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy
M Javle, NJ Curtin - Therapeutic advances in medical …, 2011 - journals.sagepub.com
The modulation of DNA repair pathways for therapeutic benefit in cancer has now become a
reality with the development of poly (ADP-ribose) polymerase inhibitors (PARPi). PARP is …
reality with the development of poly (ADP-ribose) polymerase inhibitors (PARPi). PARP is …
[HTML][HTML] SUMOylation and de-SUMOylation in response to DNA damage
H Dou, C Huang, T Van Nguyen, LS Lu, ETH Yeh - FEBS letters, 2011 - Elsevier
To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA
from the damage generated by environmental agents or DNA metabolism. SUMO (small …
from the damage generated by environmental agents or DNA metabolism. SUMO (small …
[HTML][HTML] Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair
The sirtuin gene family comprises an evolutionarily ancient set of NAD+ dependent protein
deacetylase and mono-ADP ribosyltransferase enzymes. Found in all domains of life …
deacetylase and mono-ADP ribosyltransferase enzymes. Found in all domains of life …
Poly (ADP-ribose) polymerase-1 inhibition: preclinical and clinical development of synthetic lethality
M Leung, D Rosen, S Fields, A Cesano, DR Budman - Molecular medicine, 2011 - Springer
The hereditary forms of breast cancer identified by BRCA1 and BRCA2 genes have a defect
in homologous DNA repair and demonstrate a dependence on alternate DNA repair …
in homologous DNA repair and demonstrate a dependence on alternate DNA repair …
The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest
DL Madison, D Stauffer, JR Lundblad - DNA repair, 2011 - Elsevier
Poly (ADP)-ribose polymerase (PARP) inhibitors modify the enzymatic activity of PARP1/2.
When certain PARP inhibitors are used either alone or in combination with DNA damage …
When certain PARP inhibitors are used either alone or in combination with DNA damage …
The ups and downs of tannins as inhibitors of poly (ADP-ribose) glycohydrolase
C Blenn, P Wyrsch, FR Althaus - Molecules, 2011 - mdpi.com
DNA damage to cells activates nuclear poly (ADP-ribose) polymerases (PARPs) and the
poly (ADP-ribose)(PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR …
poly (ADP-ribose)(PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR …