As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated
angiogenesis is a promising tactic in limiting cancer progression. The tumor …

During angiogenesis, αv integrins are overexpressed on the endothelial cell surface to
facilitate the growth and survival of newly forming vessels. Accordingly, blocking αv integrin …

How individual components of the vascular basement membrane influence endothelial cell
behaviour remains unclear. Here we show that laminin α4 (Lama4) regulates tip cell …

Integrins are a family of cell-extracellular matrix adhesion molecules that play important
roles in tumor angiogenesis. αvβ3-Integrin has received much attention as a potential anti …

A cell surface receptor for thyroid hormone that activates extracellular regulated kinase
(ERK) 1/2 has been identified on integrin αvβ3. We have examined the actions of thyroid …

Rationale: Integrins play a crucial role in controlling endothelial cell proliferation and
migration during angiogenesis. The Delta-like 4 (Dll4)/Notch pathway establishes an …

Vascular endothelial growth factor (VEGF) acting through VEGF receptor 2 (VEGFR2) on
endothelial cells (ECs) is a key regulator of angiogenesis, a process essential for wound …

Angiogenesis is the formation of new blood vessels from pre-existing structures, and is a key
step in tissue and organ development, wound healing and pathological events. Changes in …

The term angiogenesis arose in the 18th century. Several studies over the next 100 years
laid the groundwork for initial studies performed by the Folkman laboratory, which were at …

Integrin α9β1 mediates accelerated cell adhesion and migration through interactions with a
number of diverse extracellular ligands. We have shown previously that it directly binds the …