The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression
G Masi, P Brovedani - CNS drugs, 2011 - Springer
Depression is a prevalent, highly debilitating mental disorder affecting up to 15% of the
population at least once in their lifetime, with huge costs for society. Neurobiological …
population at least once in their lifetime, with huge costs for society. Neurobiological …
Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling? Neuronal life, growth and death signalling are crucially regulated by intra …
S Skeldal, D Matusica, A Nykjaer, EJ Coulson - Bioessays, 2011 - Wiley Online Library
The common neurotrophin receptor (p75NTR) regulates various functions in the developing
and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and …
and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and …
Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4
VA Skucas, IB Mathews, J Yang, Q Cheng… - Journal of …, 2011 - Soc Neuroscience
Aquaporin-4 (AQP4) is the major water channel in the CNS and is primarily expressed in
astrocytes. Little is known about the potential for AQP4 to influence synaptic plasticity …
astrocytes. Little is known about the potential for AQP4 to influence synaptic plasticity …
Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation
SF Evans, K Irmady, K Ostrow, T Kim, A Nykjaer… - Journal of Biological …, 2011 - ASBMB
Brain-derived neurotrophic factor (BDNF) regulates neuronal differentiation, synaptic
plasticity, and morphology, and modest changes in BDNF levels results in complex …
plasticity, and morphology, and modest changes in BDNF levels results in complex …
Altering BDNF expression by genetics and/or environment: impact for emotional and depression-like behaviour in laboratory mice
S Chourbaji, C Brandwein, P Gass - Neuroscience & Biobehavioral …, 2011 - Elsevier
According to the “neurotrophin hypothesis”, brain-derived neurotrophic factor (BDNF) is an
important candidate gene in depression. Moreover, environmental stress is known to …
important candidate gene in depression. Moreover, environmental stress is known to …
The role of neurotrophic factors in autism
T Nickl-Jockschat, TM Michel - Molecular psychiatry, 2011 - nature.com
Autism spectrum disorders (ASDs) are pervasive developmental disorders that frequently
involve a triad of deficits in social skills, communication and language. For the underlying …
involve a triad of deficits in social skills, communication and language. For the underlying …
Structural model for p75NTR–TrkA intracellular domain interaction: a combined FRET and bioinformatics study
MF Iacaruso, S Galli, M Martí, JI Villalta… - Journal of molecular …, 2011 - Elsevier
Nerve growth factor (NGF) is a member of the neurotrophins, which are important regulators
of embryonic development and adult function in the vertebrate nervous systems. The …
of embryonic development and adult function in the vertebrate nervous systems. The …
Peptide mimetics of neurotrophins and their receptors
SD Skaper - Current pharmaceutical design, 2011 - ingentaconnect.com
Neurotrophic factors were originally identified based on their ability to prevent naturally
occurring cell death in the developing nervous system. Many of these proteins also promote …
occurring cell death in the developing nervous system. Many of these proteins also promote …
p75NTR induces apoptosis in medulloblastoma cells
J Küchler, W Hartmann, A Waha, A Koch… - … journal of cancer, 2011 - Wiley Online Library
The classic medulloblastoma (CMB) and the desmoplastic medulloblastoma (DMB)
subtypes represent the major medulloblastoma variants. In contrast to CMB, DMB display …
subtypes represent the major medulloblastoma variants. In contrast to CMB, DMB display …
Untersuchung der Rolle von Neurotrophinen in der Zellphysiologie von Atemwegsepithelzellen am Beispiel der murinen Lungenepithelzellinie LA-4
A Pirayesh Islamian - archiv.ub.uni-marburg.de
Beim allergischen Asthma bronchiale handelt es sich um eine chronische
Atemwegsentzündung, die mit einer variablen Atemwegsobstruktion nach …
Atemwegsentzündung, die mit einer variablen Atemwegsobstruktion nach …