Many types of tumors are organized in a hierarchy of heterogeneous cell populations, with
only a small proportion of cancer stem cells (CSCs) capable of sustaining tumor formation …

The cancer stem cell (CSC) model proposes that tumors have a hierarchical organization in
which only some cells indefinitely self-renew and thereby sustain tumor growth. In addition …

Malignant gliomas contain a population of self-renewing tumorigenic stem-like cells;
however, it remains unclear how these glioma stem cells (GSCs) self-renew or generate …

The central portion of the midbody, a cytoplasmic bridge between nascent daughter cells at
the end of cell division, has generally been thought to be retained by one of the daughter …

Chronic kidney disease (CKD) is a progressive loss in renal function over a period of months
or years. End-stage renal disease (ESRD) or stage 5 CKD ensues when renal function …

Successful brain development requires tight regulation of sequential symmetric and
asymmetric cell division. Although Pax6 is known to exert multiple roles in the developing …

The differentiation of stem cells is a fundamental process in cell biology and understanding
its mechanism might open a new avenue for therapeutic strategies. Using an ex vivo co …

MicroRNAs (miRNAs) have been shown to play an important role in hematopoiesis. To
elucidate the role of miRNAs in the early steps of hematopoiesis, we directly compared …

The AC133 epitope expressed on the CD133 glycoprotein has been widely used as a cell
surface marker of numerous stem cell and cancer stem cell types. It has been recently …

Cell-based approaches utilizing autologous human renal cells require their isolation,
expansion in vitro, and reintroduction back into the host for renal tissue regeneration …