Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia

M Ewers, RA Sperling, WE Klunk, MW Weiner… - Trends in …, 2011 - cell.com
Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease. At the
time of clinical manifestation of dementia, significant irreversible brain damage is already …

Functional network disruption in the degenerative dementias

M Pievani, W de Haan, T Wu, WW Seeley… - The Lancet …, 2011 - thelancet.com
Despite advances towards understanding the molecular pathophysiology of the
neurodegenerative dementias, the mechanisms linking molecular changes to …

DTI analyses and clinical applications in Alzheimer's disease

K Oishi, MM Mielke, M Albert… - Journal of Alzheimer's …, 2011 - content.iospress.com
DTI is one of the most effective MR tools for the investigation of the brain anatomy. In
addition to the gray matter, histopathological studies indicate that white matter is also a good …

Loss of neuronal integrity during progressive HIV-1 infection of humanized mice

PK Dash, S Gorantla, HE Gendelman… - Journal of …, 2011 - Soc Neuroscience
Neuronal damage induced by ongoing human immunodeficiency virus type 1 (HIV-1)
infection was investigated in humanized NOD/scid-IL-2Rγcnull mice transplanted at birth …

Structural and functional network connectivity breakdown in Alzheimer's disease studied with magnetic resonance imaging techniques

M Filippi, F Agosta - Journal of Alzheimer's Disease, 2011 - content.iospress.com
Patients with Alzheimer's disease (AD) experience a brain network breakdown, reflecting
disconnection at both the structural and functional system level. Resting-state (RS) …

Staging Alzheimer's disease progression with multimodality neuroimaging

M Ewers, GB Frisoni, SJ Teipel, LT Grinberg… - Progress in …, 2011 - Elsevier
Rapid developments in medical neuroimaging have made it possible to reconstruct the
trajectory of Alzheimer's disease (AD) as it spreads through the living brain. The current …

White matter changes in late-life depression: a diffusion tensor imaging study

SJ Colloby, MJ Firbank, AJ Thomas, A Vasudev… - Journal of affective …, 2011 - Elsevier
BACKGROUND: Numerous studies have revealed white matter abnormalities in late-life
depression (LLD). The objective was to investigate the integrity of white matter tracts in …

Role of family history for Alzheimer biomarker abnormalities in the adult children study

C Xiong, CM Roe, V Buckles, A Fagan… - Archives of …, 2011 - jamanetwork.com
Objective To assess whether family history (FH) of Alzheimer disease (AD) alone influences
AD biomarker abnormalities. Design Adult Children Study. Setting Washington University's …

Comparison of diffusion tensor image study in association fiber tracts among normal, amnestic mild cognitive impairment, and Alzheimer's patients

YZ Zhang, C Chang, X Wei, JL Fu, WB Li - Neurology India, 2011 - journals.lww.com
Aim: To compare diffusion tensor image (DTI) study in association fiber tracts among normal
control (NC), amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) …

Evaluation and tracking of Alzheimer's disease severity using resting-state magnetoencephalography

TA Verdoorn, JR McCarten… - Journal of …, 2011 - content.iospress.com
We have conducted multicenter clinical studies in which brain function was evaluated with
brief, resting-state magnetoencephalography (MEG) scans. A study cohort of 117 AD …